Pionyr Pipeline

Pionyr’s Myeloid Tuning™ programs are designed to enhance the immune system’s anti-tumor response by specifically altering the cellular infiltrate of the tumor microenvironment. Pionyr’s clinical programs, PY314 and PY159, targeting TREM2 and TREM1 respectively, are designed to selectively deplete and, in some cases, reprogram certain tumor-associated macrophages responsible for immunosuppression. PY314 and PY159 have demonstrated safety alone and in combination with pembrolizumab in Phase 1a/b trials. Pionyr’s third program, PY265 (anti-MARCO) is IND-ready.