Publications

Targeting TREM2 on tumor-associated macrophages enhances immunotherapy. / Binnewies M, Pollack JL et al. Cell Reports. 2021

Tuning the Tumor Myeloid Microenvironment to Fight Cancer. / Jahchan NS, Krummel MF et al. Frontiers Immunology. 2019

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. / Binnewies M, Krummel MF et al. Cell. 2019

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. / Barry KC, Krummel MF et al. Nature Medicine. 2018

Understanding the tumor immune microenvironment (TIME) for effective therapy. / Binnewies M, Krummel MF et al. Nature Medicine. 2018

Partially exhausted tumor-infiltrating lymphocytes predict response to combination Immunotherapy. / Loo K, Daud AI et al. JCI Insight. 2017

Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC. / Tumeh PC, Daud AI et al. Cancer Immunol Res. 2017

Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine. / Boldajipour B, Krummel MF et al. JCI Insight. 2016

Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung. / Sen D, Krummel MF et al. PLoS One. 2016

Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. / Daud AI, Rosenblum MD et al. J Clin Invest. 2016

Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. / Roberts EW, Krummel MF et al. Cancer Cell. 2016

Visualization of immediate immune responses to pioneer metastatic cells in the lung. / Headley MB, Krummel MF et al. Nature. 2016

T cell migration, search strategies and mechanisms. / Krummel MF, Gérard A et al. Nat Rev Immunol. 2016

The emerging understanding of myeloid cells as partners and targets in tumor rejection. / Broz ML, Krummel MF. Cancer Immunol Res. 2015

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. / Broz ML, Krummel MF et al. Cancer Cell. 2014

Whitepapers

Therapeutic Targeting of TREM2 - Distinct Approaches for Different Diseases / June 2022

Myeloid Tuning^TM of the Tumor Microenvironment with PY159 in Cancer Immunotherapy / July 2022